The 2- aminothiazole compounds are medicinally important agents due to their broad spectrum of biological activities. This study aims to design new 2-aminothiazole derivatives, docking, and synthesis via several steps and identified using physical and spectroscopic techniques. The bioactivities of the synthesized compounds were evaluated concerning their antimicrobial activities against were screened against five bacterial strains, Enterobact aerogenes, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus and two types of fungal strain Candida albicans and Cryptococcus neoformans var. grubii.