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180609

Synthesis of Novel Bivalent Hydrazino-Thymohydroquinone Analogs Derived from Thymoquinone as Potential Antimicrobial Agents

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

In our previous work, it was reported that thymoquinone (TQ) and some thymohydroquinone (THQ) derivatives were used as precursors for the synthesis of potential anticancer agents. Hence, as a part of our ongoing program in the design of biologically active compounds derived from TQ scaffold we herein investigated the synthesis of homo- and heteronuclear thymol dimers tethered through various linkers such as ethylene, butylene, acetyl and N,N'-acetyl piperazine groups. The newly prepared compounds were examined as antimicrobial agents. Compounds 7 and 8 bearing a piperazine moiety exhibited highest antibacterial activity comparing to TQ, THQ and ampicillin especially against Staphylococcus aureus bacteria with MIC value of 16 µg/mL. All compounds showed moderate antifungal activity against Candida albicans and Aspergillus fumigatus. Together, the new TQ-based bivalent lead might be serving as a promising scaffold for development of novel and potent antimicrobial agents.

DOI

10.21608/ejchem.2021.74154.3743

Keywords

Thymoquinone, Thymohydroquinone, Antimicrobial, Bivalent, Heteronuclear dimer

Authors

First Name

Ahmed

Last Name

Abdelazeem

MiddleName

H.

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt; Department of Pharmaceutical Sciences, College of Pharmacy, Riyadh Elm University, Riyadh 11681, Saudi Arabia.

Email

ahmed.abdelazeem@pharm.bsu.edu.eg

City

Beni-Suef

Orcid

0000-0002-0599-3393

First Name

Hany

Last Name

Arab

MiddleName

H

Affiliation

Department of Pharmacology and Toxicology-Biochemistry division, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Email

hanyhamdy5555@yahoo.com

City

Taif

Orcid

-

First Name

Alaa M.

Last Name

Alqahtani

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia;

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Badway

MiddleName

F.

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, University of Sadat City, 32897, Menuofia, Egypt

Email

mohamedbadawyyy@yahoo.com

City

Menuofia

Orcid

-

First Name

Yasser

Last Name

Mohamed

MiddleName

Mahmoud Ali

Affiliation

Photochemistry Department, National Research Center, Dokki, Giza, 12622, Egypt.

Email

y.m.a.mohamed@outlook.com

City

Giza

Orcid

0000-0003-4678-9767

Volume

64

Article Issue

12

Related Issue

27765

Issue Date

2021-12-01

Receive Date

2021-05-17

Publish Date

2021-12-01

Page Start

7,229

Page End

7,234

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 12_Pages 7229-7234.pdf

PDF . 315.4kB

Link

https://ejchem.journals.ekb.eg/article_180609.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=180609

Order

38

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis of Novel Bivalent Hydrazino-Thymohydroquinone Analogs Derived from Thymoquinone as Potential Antimicrobial Agents

Details

Type

Article

Created At

22 Jan 2023