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191191

Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, and dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from the reaction of Luminol (1) with thiating Lawesson and Japanese reagents. Structures of the synthesized compounds were clarified based on their elemental and spectroscopic analyses. The synthesized compounds were evaluated for their antimicrobial activity against some bacterial and fungal strains.

DOI

10.21608/ejchem.2021.88648.4263

Keywords

Luminol, Wittig, Trialkyl phosphite, antimicrobial activity

Authors

First Name

Ewies

Last Name

Ewies

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

ewiesfawzy@yahoo.com

City

Giza

Orcid

0000-0002-4832-5766

First Name

Naglaa

Last Name

El-Sayed

MiddleName

Fathy

Affiliation

Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.

Email

naglaa2778@yahoo.com

City

-

Orcid

0000-0002-3226-9093

First Name

Marwa

Last Name

El-Hussieny

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, Chemical Industries Division, NRC, Egypt.

Email

mrw_elhussieny@yahoo.com

City

-

Orcid

0000-0002-5491-0750

First Name

Mohamed

Last Name

Abdelaziz

MiddleName

-

Affiliation

Microbial Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt

Email

mohabomerna@yahoo.ca

City

-

Orcid

-

Volume

64

Article Issue

12

Related Issue

27765

Issue Date

2021-12-01

Receive Date

2021-08-01

Publish Date

2021-12-01

Page Start

7,165

Page End

7,173

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 12_Pages 7165-7173.pdf

PDF . 632.1kB

Link

https://ejchem.journals.ekb.eg/article_191191.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=191191

Order

31

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023