Pre-eclampsia is characterized by an increase in blood pressure and proteinuria. The aim of this study was to determine the concentrations of TNF-α in the maternal blood in patients suffering from pre-eclampsia. Patients and methods a cross sectional study was conducted in Sallah Alddin general hospital/Tikrit city from beginning of March to the end of August 2019. The current research focuses on determining of TNF-α level in pregnancy toxemia in Tikrit city- Iraq. Sixty pregnant women are enrolled in the study thirty of them are suffering from hypertension and albumin urea in the third trimester, age (17-36) years and other thirty are healthy pregnant as control age (17-38) years. All blood samples are tested for Tumor Necrosis Factor-α (TNF-α), C- reactive protein (CRP), albumin, uric acid, liver functions, and lipid profile. The results showed a significant increase, for patient's women, in the serum TNF-α, CRP, liver enzymes, LDL, triglyceride (TG), cholesterol. While the HDL show significant decrease and non-significant differences regarding serum albumin and uric acid between patients and controls.