This paper presents a study in the electrochemical methods for the preparation three new electrodes of Fexofenadine hydrochloride in a polymeric membrane. The first electrode was prepared from ion pair: molybdophosphoric acid reagent and fexofenadine cation with Di-n-butyl phthalate (DBPH), the subsequent electrode was prepared with O-Nitro phenyl octyl ether( NPOE) and the third electrode was set up by Tri-n-butyl phthalate (TBP), respectively as a plasticizers for determination of Fexofenadine hydrochloride drug. Two electrodes indicated a Nernstian response with a slope of [57.01, 56.70] mV.decade−1 for the first and second electrodes individually, with detection limits 5.6×10-6 mole.L-1 for first electrode and 3.5×10-6 mole.L-1 for second electrode and the third electrode was gave a non Nernstain response equivalent to 14.30 mV.decade−1. The electrodes work adequately over pH range (2.0-4.5),(2.5-4.0) and (2.0- 4.0) for Fexofenadine hydrochloride electrodes. The impact of interfering species was insignificant as demonstrated by selectivity coefficient values. The viability of the electrodes proceeded in a timeframe (41,36,and 13) days. The recommended electrodes were successfully used for the determination of Fexofenadine hydrochloride in pure form and pharmaceuticals preparations. This work arrived at excellent outcomes as far as the linearity, exactness, selectivity, and accuracy of the methods.