Hiren safflower dye nanoparticles were successfully prepared by using simple ball milling technique at room temperature. UV-vis. absorption, XRD, TEM, FT-IR spectroscopy and SEM were used to characterize safflower dye nanoparticles. The prepared safflower dye nanoparticles were used as active ingredient for printing cotton, wool and polyester fabrics via dye printing technique and pigment printing technique. Factors of printing process were studied such as Mordanting of Substrates, thickeners type, urea concentration and Printing Paste pH for first paste and urea concentration, Printing Paste pH and binder concentration for second paste. Results shows fabrics printed with safflower dye nanoparticles via mentioned two methods shows very good to excellent fastness properties with full green method. These data indicated that printed samples have high quality for colour strength without any environmental hazards compared with other conventual and nanotechnological aspects.