The research included preparing nanoparticle ferric oxide and then diagnosing it with several techniques including scanning electron microscopy technology (SEM) and transmission electron microscopy (TEM) and Energy-dispersive X-ray (EDX), and this research also included a thermodynamic study of adsorption of a mixture of nolvadex with nano ferric oxide prepared on a surface of Activated charcoal, as it was found that the equilibrium time was 40-50 minutes and an appropriate weight of the adsorbent 0.1 g, The study was carried out at four different temperatures (290.65-320.65 K), as it was found that the adsorption process was Spontaneous (ΔGo = -) and Exothermic (ΔH= -) A few Random (ΔSo =-).