The present work involved the preparation of mixed composite derivatives from phosphate glass and polyaniline together with additional doped samples containing increasing CuO or ZnO (3→10 mol%). All prepared pure glass and polyaniline together with their composites were characterized by structural FTIR analysis, X-ray diffraction examinations and surface scanning electron microscope (SEM). Further antimicrobial properties of the base glass, base polyaniline and composites with one of the two dopants (CuO,ZnO) were studied and evaluated. FT infrared spectrum of the base undoped glass revealed vibrational bands due to PO4 tetrahedral groups which are extended from 400 cm-1 to 1500 cm-1 within the mid region. The base polyaniline exhibits extended vibrational bands characteristic for vibrations of C – C, C- H, C = C and N – H groupings. The composite (glass + polyaniline) showed mixed or interfering vibrations of all constitutional groupings. The dopant oxides showed only limited variations to the IR spectra. X-ray diffraction patterns of base and doped glass samples revealed only undefined humps with no indication for crystalline species but only amorphous structures. On the other hand, polyaniline revealed two diffraction peaks which were correlated with crystalline components of the polymerized granular texture of the (PANI). SEM investigations revealed mostly amorphous texture for the parent glass and its derivatives but the polyaniline exhibited granular texture which extended to all composites in different forms. Glass and polyaniline composites showed varying responses to micro-organisms. In general, the composites showed favourable data.