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165692

Synthesis, Characterization, Antimicrobial, MTT assay, DFT study of Co(II), Ni(II), Cu(II) and Zn(II) Complexes with some New Schiff Base Ligands

Article

Last updated: 22 Jan 2023

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Subjects

-

Tags

Inorganic chemistry

Abstract

Novel Schiff base ligand HL was synthesized by the condensation of 3,5- dichlorosalicylaldehyde and 4-phenylsemicarbazide. Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized in 1:1 molar ratio of metal to ligand. The structure of the synthesized ligand was established using 1H NMR, IR, Mass spectrometry and the metal complexes were characterized using IR, Mass spectrometry, UV-Vis, powdered XRD and molar conductivity. The thermal stability of the complex was studied by TGA. In DFT studies, the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy taking the 6-31+g (d,p) basis set using Gaussian 09w, several molecular properties were also calculated. The spectral data show that ligand HL behaves as uninegative tridentate. On the basis of spectral studies, an octahedral geometry has been assigned for Co(II), square planar for Cu(II) and tetrahedral for Ni(II) and Zn(II) complexes. The antimicrobial activities were examined against some human pathogenic strains. The MTT assay was screened against mouse fibroblast cell line. The result indicates that metal complexes show increase in cytotoxicity in proliferation to cell line as compared to the free ligand.

DOI

10.21608/ejchem.2021.47433.2964

Keywords

Schiff base, Metal complexes, powdered XRD, DFT, Antimicrobial, MTT assay

Authors

First Name

Deepak

Last Name

Tomar

MiddleName

-

Affiliation

Department of Chemistry, University of Delhi, Delhi, Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi, India

Email

deepaktomar537@gmail.com

City

-

Orcid

-

First Name

Madhuri

Last Name

Chaurasia

MiddleName

-

Affiliation

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, New Delhi, India

Email

madhurichaurasia2011@gmail.com

City

-

Orcid

-

First Name

Prateek

Last Name

Tyagi

MiddleName

-

Affiliation

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, New Delhi, India

Email

tyagi.prtk@gmail.com

City

-

Orcid

-

First Name

Swati

Last Name

Agrawal

MiddleName

-

Affiliation

Department of Chemistry, Motilal Nehru College, University of Delhi, New Delhi, India

Email

-

City

-

Orcid

-

First Name

Pravita

Last Name

Kumar

MiddleName

-

Affiliation

Department of Chemistry, Sri Aurbindo College, University of Delhi, New Delhi, India

Email

-

City

-

Orcid

-

First Name

Deepansh

Last Name

Sharma

MiddleName

-

Affiliation

Amity Institute of Microbial Technology, Amity University, Jaipur, Rajasthan, India

Email

deepanshsharma@gmail.com

City

-

Orcid

-

First Name

Aruna

Last Name

Chhikara

MiddleName

-

Affiliation

Department of Chemistry, Dyal Singh College, University of Delhi, New Delhi, India

Email

arunachikkara@gmail.com

City

-

Orcid

-

First Name

Sulekh

Last Name

Chandra

MiddleName

-

Affiliation

Department of Chemistry, Zakir Husain Delhi College, University of Delhi, New Delhi, India

Email

schandra_00@yahoo.com

City

New Delhi

Orcid

0000-0002-5439-5330

Volume

64

Article Issue

9

Related Issue

27062

Issue Date

2021-09-01

Receive Date

2020-10-22

Publish Date

2021-09-01

Page Start

4,995

Page End

5,008

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 9_Pages 4995-5008.pdf

PDF . 982.7kB

Link

https://ejchem.journals.ekb.eg/article_165692.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=165692

Order

29

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023