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165695

An Improved Synthesis of Pentapeptide (SCAP1e) Using Solid-Phase Method with Reduced Resin Loading Time

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

SCAP1e is an alanine-rich-pentapeptide, analog of SCAP1 an antioxidant peptide. The previous solid-phase synthesis on this peptide resulted in low yield of the product (7%) due to the aggregation that might occur during synthesis. The aim of the research was to resynthesize this peptide using the similar method but with a slight modification in the resin loading step. SCAP1e was successfully synthesized through solid-phase method with an improved yield 87.9% and high purity (90.2%) based on the HPLC analysis. The reduction of resin loading value from 1.2 mmol/gram to 0.63 mmol/gram has made a good impact for the improvement of the synthetic yield.

DOI

10.21608/ejchem.2021.52601.3085

Keywords

Solid-phase peptide synthesis, resin loading, Aggregation, SCAP1, SCAP1e

Authors

First Name

Rani

Last Name

Maharani

MiddleName

-

Affiliation

Department of Chemistry Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia Central Laboratory Universitas Padjadjaran, Jl. Raya BandungSumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia

Email

r.maharani@unpad.ac.id

City

Bandung

Orcid

-

First Name

Mufti

Last Name

Amrullah

MiddleName

Hanif

Affiliation

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran

Email

muftihanif28@gmail.com

City

Jatinangor

Orcid

-

First Name

Dessy

Last Name

Kurnia

MiddleName

Yulyani

Affiliation

Department of Chemsitry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran

Email

dessyyulyanikurnia@gmail.com

City

-

Orcid

-

First Name

Ace

Last Name

Hidayat

MiddleName

Tatang

Affiliation

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran

Email

ace.hidayat@unpad.ac.id

City

Jatinangor

Orcid

-

First Name

Nurlelasari

Last Name

Nurlelasari

MiddleName

-

Affiliation

Department of Chemistry Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia

Email

nurlelasari@unpad.ac.id

City

Bandung Area, West Java, Indonesia

Orcid

-

First Name

Desi

Last Name

Harneti

MiddleName

-

Affiliation

Department of Chemistry Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia

Email

desi.harneti@unpad.ac.id

City

Bandung Area, West Java, Indonesia

Orcid

-

First Name

Unang

Last Name

Supratman

MiddleName

-

Affiliation

Department of Chemistry Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia Central Laboratory Universitas Padjadjaran, Jl. Raya BandungSumedang Km 21 Jatinangor 45363, Sumedang, West Java, Indonesia

Email

unang.supratman@unpad.ac.id

City

Bandung Area, West Java, Indonesia

Orcid

-

Volume

64

Article Issue

9

Related Issue

27062

Issue Date

2021-09-01

Receive Date

2020-12-06

Publish Date

2021-09-01

Page Start

4,797

Page End

4,801

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 9_Pages 4797-4801.pdf

PDF . 279.1kB

Link

https://ejchem.journals.ekb.eg/article_165695.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=165695

Order

8

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

An Improved Synthesis of Pentapeptide (SCAP1e) Using Solid-Phase Method with Reduced Resin Loading Time

Details

Type

Article

Created At

22 Jan 2023