Spirulina spp. is an alga from phylum Cyanobacteria that have multi-benefit due to their potential compounds like protein, carbohydrate, lipid, mineral, pigment, and phenolic compounds. Several types of research already describe Spirulina spp. capacity as an antioxidant, anti-inflammation, and antimicrobial agent, thus expand its application as a food source, cosmeceutical, and pharmaceutical compound. This study observed and evaluated Spirulina spp. extract as a potential source for cosmeceutical compound antioxidant and wound healing activities. Spirulina spp. was extracted with a variable solvent like water, ethanol, acetic acid, and buffer for 1 and 3 hours by the maceration method. Spirulina extract which give the highest antioxidants activity, was evaluated for wound healing, toxicity, and irritation. The result showed that Spirulina spp. water extracted for one hour using the maceration method have the highest antioxidant capacity with IC50 45.21 mg/mL, AEAC 0.12 mg Vit. C/g sample, phycocyanin content 6.478 µg/ml, and chlorophyll content 2.642 µg/ml. Treatment with 1% Spirulina extracts exhibits a higher wound healing effect rather than 10% Spirulina spp. extract, control group, and povidone-iodine 10%, on Wistar rat skin. Spirulina spp. water extract showed capacity as a whitening agent with inhibitory activity on tyrosinase were IC50 0.51 mg/mL. Spirulina spp. water extract had no irritation and toxicity effect on rabbit skin and mouse, respectively. This study showed that Spirulina spp. water extract is a potential source for antioxidant activity, wound healing capacity, and whitening agent; without toxicity and irritation effect. The result showed that Spirulina spp. extract could be potential value in cosmeceutical application.