Beta
ManageSearchChatDiscover
160202

Synthesis and characterization of new 1,2,4-triazole anticancer scaffold derivatives: In Vitro study

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Four Schiff bases were obtained via one direct click reaction between 3-amino-1H-1,2,4-triazole and different substituted benzaldehyde. The synthesized compounds were characterized on the basis of their spectral data including IR spectra and 1HNMR. The synthesized compounds were tested against three human cancer cell lines to evaluate their in vitro anticancer activity, and also tested on Vero cells extracted from African green monkey kidney to investigate their side effect. The screening showed that the Schiff bases TB-NO2 and TB-OCH3 produced an effective anticancer activity against HEPG2, HCT-116, and MCF-7 cell lines. Further investigations were performed to determine the apoptotic and antifibrotic ability of TB-NO2 and TB-OCH3 on MCF-7 cells by determining the expression of Bax, Bcl-2, CTGF, and PDGF. Results of Bax/Bcl-2 ratio for TB-NO2 and TB-OCH3 confirmed the apoptotic effect of these compounds on MCF-7 cells. The reduction in CTGF and PDGF genes expression confirmed the regulatory effect of these compounds on MCF-7 cells growth.

DOI

10.21608/ejchem.2021.64760.3386

Keywords

Anticancer activity, 1,2,4-triazole, Schiff base, Cytotoxicity, In-vitro

Authors

First Name

Nabila

Last Name

Zein

MiddleName

-

Affiliation

Biochemistry Division, Chemistry Department Faculty of Science, Zagazig University, Egypt

Email

nabilazein@yahoo.com

City

-

Orcid

-

First Name

Samy M.

Last Name

Shaban

MiddleName

-

Affiliation

School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea., Egyptian Petroleum Research Institute, Cairo, Egypt.

Email

dr.samyshaban@yahoo.com

City

cairo

Orcid

-

First Name

Samir Hosny

Last Name

Shafek

MiddleName

-

Affiliation

Egyptian Petroleum Research Institute, Cairo, Egypt.

Email

shshafek@yahoo.com

City

-

Orcid

-

First Name

Hamza

Last Name

Baghi

MiddleName

-

Affiliation

Biochemistry Division, Chemistry Department Faculty of Science, Zagazig University, Egypt

Email

hamzabaghi@yahoo.com

City

cairo

Orcid

-

First Name

I.

Last Name

Aiad

MiddleName

-

Affiliation

Egyptian Petroleum Research Institute, Cairo, Egypt.

Email

yiaiad@yahoo.co.uk

City

cairo

Orcid

-

First Name

Mervat

Last Name

Omran

MiddleName

-

Affiliation

Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

mervatomran@yahoo.com

City

cairo

Orcid

-

Volume

64

Article Issue

8

Related Issue

26586

Issue Date

2021-08-01

Receive Date

2021-02-23

Publish Date

2021-08-01

Page Start

4,005

Page End

4,015

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 8_Pages 4005-4015.pdf

PDF . 777.6kB

Link

https://ejchem.journals.ekb.eg/article_160202.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=160202

Order

4

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and characterization of new 1,2,4-triazole anticancer scaffold derivatives: In Vitro study

Details

Type

Article

Created At

22 Jan 2023