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176668

Design, Synthesis and Antiviral Evaluation of New N-(4)-(benzo[d][1,3]-dioxol-5-yl)thiosemicarbazone Derivatives

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

A new series of N-(4)-substituted thiosemicarbazone derivatives 4-8 incorporating a benzo[d][1,3]dioxole moiety were synthesized through the reaction of N-(4)-(benzo[d][1,3]dioxol-5-yl)-thiosemicarbazide with various carbonyl compounds such as aromatic aldehyde, heterocyclic aldehyde, acetophenone, heterocyclic ketone and cyclic ketone derivatives. The structure of the prepared thiosemicarbazones was established based on spectroscopic IR, 1H-NMR, 13C-NMR and elemental analyses data. The antiviral activity of the synthesized compounds was tested against Bovine Viral Diarrhea Virus (BVDV).

DOI

10.21608/ejchem.2021.72649.3603

Keywords

Thiosemicarbazones, thiosemicarbazide, benzo[d][1, 3]dioxole, Antiviral, BVDV

Authors

First Name

Samir Y.

Last Name

Abbas

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Email

samiryoussef98@yahoo.com

City

-

Orcid

-

First Name

Wael M.

Last Name

Tohamy

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Email

wael_tohamy79@hotmail.com

City

-

Orcid

0000-0003-0680-3085

First Name

Wahid M.

Last Name

Basyouni

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Email

w_basyouni2002@yahoo.com

City

-

Orcid

-

First Name

Khairy A.M.

Last Name

El-Bayouki

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Email

bayouki_2012@yahoo.com

City

-

Orcid

-

First Name

Reham M.

Last Name

Dawood

MiddleName

-

Affiliation

Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt

Email

rmhaemd@hotmail.com

City

-

Orcid

-

First Name

Mostafa K.

Last Name

El-awady

MiddleName

-

Affiliation

Microbial Biotechnology Department, National Research Centre, Dokki, Cairo, Egypt

Email

mkawady49@yahoo.com

City

-

Orcid

-

First Name

Farid M.

Last Name

Sroor

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt

Email

faridsroor@yahoo.com

City

-

Orcid

0000-0003-1283-2157

Volume

64

Article Issue

7

Related Issue

25275

Issue Date

2021-07-01

Receive Date

2021-04-16

Publish Date

2021-07-01

Page Start

3,791

Page End

3,800

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 7_Pages 3791-3800.pdf

PDF . 408.8kB

Link

https://ejchem.journals.ekb.eg/article_176668.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=176668

Order

55

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Design, Synthesis and Antiviral Evaluation of New N-(4)-(benzo[d][1,3]-dioxol-5-yl)thiosemicarbazone Derivatives

Details

Type

Article

Created At

22 Jan 2023