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Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzoylisothiocyanate and aminopyrazoles. The antimicrobial activities were also studied and have been found that; Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species

DOI

10.21608/ejchem.2021.65453.3404

Keywords

p-Aminobenzoic acid, 3-oxobutanamides, pyrimidines, Pyridines, thiophenes and antimicrobial activity

Authors

First Name

Ahmed

Last Name

El-Shareef

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.

Email

ahmedkhames.42@azhar.edu.eg

City

-

Orcid

-

First Name

Abdelhaleem

Last Name

Hussein

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.

Email

abdelhaleemmh@yahoo.com

City

-

Orcid

-

First Name

Abubaker

Last Name

Eladasy

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.

Email

a_eladasy@yahoo.com

City

-

Orcid

-

First Name

Ismail

Last Name

Othman

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.

Email

ismail201179@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Khames

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, 71524 Assiut, Egypt.

Email

a.khames@yahoo.com

City

-

Orcid

0000-0002-0536-1935

Volume

64

Article Issue

7

Related Issue

25275

Issue Date

2021-07-01

Receive Date

2021-02-28

Publish Date

2021-07-01

Page Start

3,691

Page End

3,701

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 7_Pages 3691-3701.pdf

PDF . 823.7kB

Link

https://ejchem.journals.ekb.eg/article_161117.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=161117

Order

46

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis and antibacterial evaluation of some new pyrimidine, pyridine and thiophene derivatives

Details

Type

Article

Created At

22 Jan 2023