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159605

Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

The objective of this study was to evaluate the potential toxicity of methanolic extracts of Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens). Single oral dosage was administered to male mice at increasing concentrations of 100, 250,500,1000 and 2000 mg/kg body weight to assess the median LD50, which causes the death of 50% (one half) of the mice. Blood samples were collected at the end of the 14 day toxicological trial for the liver and kidney function tests. The results showed that the LD50 of P. roxburghii was 1708.3 mg/ kg body weight and of N. graveolens 1562.5 mg/kg body weight. The acute toxicity had detrimental effects on the liver and kidney function. Based on this finding, a second trial was designed, and the mice were administered day after day intragastrically one tenth (1/10) the LD50 of each plant extract for a whole month. At the termination of the 30-day trial, blood samples and organs were collected for liver and kidney function tests. The long-term administration of 1/10 the LD50 dosages had no significant adverse effects neither on the liver and kidney functions nor on the histopathological examination. In conclusion, further studies are warranted to determine the potential application of these plant as natural therapeutic products.

DOI

10.21608/ejchem.2021.64882.3391

Keywords

P. roxburghii branch, N. graveolens, Acute toxicity, LD50, liver and kidney function

Authors

First Name

Mosab

Last Name

Gad

MiddleName

-

Affiliation

National research centre, Nutrition and food Science Department

Email

mosabalgalaly@yahoo.com

City

giza

Orcid

-

First Name

Hassan

Last Name

Z. Hassouna

MiddleName

-

Affiliation

Nutrition and Food Science Department, National Research Centre, 12622, Giza, Egypt.

Email

hz.hassouna@hotmail.com

City

Giza

Orcid

-

First Name

khaled

Last Name

mahmoud

MiddleName

-

Affiliation

Pharmacognosy Department, National Research Centre, 12622, Giza, Egypt.

Email

khaledmmh2003@yahoo.com

City

-

Orcid

0000-0002-1364-4951

First Name

Ahmed A.

Last Name

Abd-Rabou

MiddleName

-

Affiliation

Hormones Department, Medical Research Division, 2Stem Cell Laboratory, Center of Excellence for Advanced Science, National Research Centre, 12622, Giza, Egypt.

Email

ahmedchemia87@yahoo.com

City

-

Orcid

0000-0002-9875-7591

First Name

Amal S.

Last Name

Abdel-Azeem

MiddleName

-

Affiliation

Nutrition and Food Science Department, National Research Centre, 12622, Giza, Egypt.

Email

amalsaid64@yahoo.com

City

Cairo

Orcid

-

First Name

Amany M.

Last Name

Hegazy

MiddleName

-

Affiliation

Nutrition and Food Science Department, National Research Centre, 12622, Giza, Egypt

Email

dr.amany.hegazy@hotmail.com

City

Giza

Orcid

-

First Name

Mohamed S.

Last Name

Abdel- Lattife

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.

Email

healthcaresaad27@gmail.com

City

Cairo

Orcid

-

First Name

Fouad A.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Agriculture, Cairo University, 12613, Giza, Egypt.

Email

fouad_ahmed46@yahoo.com

City

Cairo

Orcid

-

Volume

64

Article Issue

7

Related Issue

25275

Issue Date

2021-07-01

Receive Date

2021-02-24

Publish Date

2021-07-01

Page Start

3,489

Page End

3,498

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 7_Pages 3489-3498.pdf

PDF . 900.0kB

Link

https://ejchem.journals.ekb.eg/article_159605.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=159605

Order

27

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice

Details

Type

Article

Created At

22 Jan 2023