Five and seven-membered heterocyclic compounds were prepared from mefenamic acid, which was esterified with absolute ethanol to give amino benzoate (Z1). The ester reaction with hydrazine hydrate gave benzohydrazide (Z2), then converted into Schiff base by using p-hydroxy benzaldhyde to give hydroxy benzylidene (Z3). Then the compound (Z4) gets us by reaction hydroxy benzylidene (Z3) with 2-mercoptoacetic acid. The interaction between benzohydrazide (Z2) and Cs2 with NaOH gave salt (Z5), which was acidified with HCl to give thiol (Z6). The compound (Z6) treated with hydrazine hydrate gave hydrazine (Z7), then converted into Schiff base by using benzaldhyde towards oxadiazol (Z8), which was interaction with maleic and phthalic anhydrides to give (Z9, Z10) respectively. The compounds that attended were diagnosed with their FTIR, 13C-NMR, and 1H-NMR spectral data. The aim of this study is to prepare heterocyclic compounds derived from mefenamic acid that may be used in the field of the medicinal drug industry.