Abstract:
New complexes with a mixture of aspirin (acetylsalicylic acid ) with methyldopa or paracetamol with methyldopa were synthesized via the reflux of reaction mixture using a basic medium to deprotonate the ligands.
These new complexes of Mn(II), Fe(II), Co(II), Ni(II) and Cu(II) with a mixture of aspirin (acetylsalicylic acid ), paracetamol and methyldopa have characterized using FTIR , UV-visible spectra, magnetic susceptibility, flame atomic absorption, C.H.N.S analysis and melting points measurements.
The two mixed ligands have been found to act as bidentate chelating agents. Aspirin (acetylsalicylic acid) complexes coordinate to the metal ions through the oxygen of Aspirin's ester group and oxygen of the carboxyl group, while Methyldopa as ligand is coordinated through the oxygen of the hydroxyl group and the nitrogen of the amide groups. The Paracetamol was coordinated through the oxygen atom of carboxyl group and the nitrogen atom of the amide group.
The stability of these new complexes depends on the size of the chelate rings, thus these ligands with a flexible organic backbone and their complexes contain five and six membered chelate rings, which have almost no strain. The molar conductance measurements for the metal complexes show non-electrolytic behavior in DMF solvent.
The all synthesized complexes which show non-electrolytic properties, also were no conducting electrical current behaved as bi-dentate with octahedral geometrical isomers.