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140621

RANTES as a novel biomarker for atherogenic dyslipidemia and metabolic disturbances in patients with Type 2 Diabetes

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Biochemistry

Abstract

RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted) is a chemokine engaged in the pathophysiology of diabetes type 2 (T2DM), related cardiovascular complications, dyslipidemia and hypertension that are major modifiable risk factors of T2DM. VEGF (Vascular endothelial growth factor) plays a role in diabetic vascular complications. Atherogenic dyslipidemia (AD) is a lipid aberration defined as the incidence of raised triglycerides (TG) and dimished high-density lipoprotein cholesterol (HDL-C) and associated with residual cardiovascular risk. However, the association between chemokine and type 2 diabetes (T2DM) and metabolic disturbances is still unclear, and few data are available. The aim of this study was to estimate serum RANTES, serum lipid composition, VEGF, and metabolic syndrome (MS) in patients with T2DM and elucidate their relationship in a sample of Egyptian premenopausal women. Serum level of RANTES, VEGF, lipids and body composition were assessed in 100 premenopausal women with T2DM (mean age 35 years old) and 100 healthy controls. Significant increase in serum RANTES level and VEGF was observed in T2DM compared to the control group. Positive correlations between elevated RANETS and increased values of VEGF, body mass index (BMI), waist circumference (WC), fat mass, LDL-C, TG, total cholesterol and presence of MS were observed in T2DM patients. Elevated RANTES concentration is associated with AD risk, abnormal metabolic components and VEGF levels. This study pinpoints the importance of RANTES as a novel biomarker for dyslipidemia and metabolic disturbance in T2DM patients.

DOI

10.21608/ejchem.2021.55814.3177

Keywords

RANTES, VEGF, Type 2 Diabetes, Atherogenic dyslipidemia, BMI

Authors

First Name

Moushira

Last Name

Zaki

MiddleName

-

Affiliation

Biological Anthropology Department, National Research Centre, Giza, Egypt.

Email

moushiraz@yahoo.com

City

Cairo

Orcid

-

First Name

Sanaa

Last Name

Kamal

MiddleName

-

Affiliation

Biological Anthropology Department, National Research Centre, Giza, Egypt.

Email

sanaa@yahoo.com

City

-

Orcid

-

First Name

Hala

Last Name

El-Bassyouni

MiddleName

T

Affiliation

Clinical Genetics Department, National Research Centre, Cairo, Egypt.

Email

lbassyouni@yahoo.com

City

-

Orcid

-

First Name

Mona Abd Elmotaleb A.

Last Name

Hussein

MiddleName

-

Affiliation

Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt

Email

abd@yahoo.com

City

-

Orcid

-

First Name

Hend M.

Last Name

Tawfeek

MiddleName

-

Affiliation

Internal Medicine Faculty of Medicine, Al-Azhar University- Girls

Email

tawfeek@yahoo.com

City

-

Orcid

-

First Name

Mina Wassef

Last Name

Girgiss

MiddleName

-

Affiliation

Medical Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

wassef@yahoo.com

City

-

Orcid

-

First Name

Nadia

Last Name

Ahmed

MiddleName

-

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

mohamed@yahoo.com

City

-

Orcid

0000-0001-9151-5920

First Name

Hisham A. Aziz

Last Name

Orban

MiddleName

-

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

orban@yahoo.com

City

-

Orcid

-

First Name

Amr

Last Name

Ibrahim

MiddleName

-

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

ibrahim@yahoo.com

City

-

Orcid

-

First Name

Eman

Last Name

Youness

MiddleName

-

Affiliation

Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt

Email

youness@yahoo.cim

City

-

Orcid

-

Volume

64

Article Issue

4

Related Issue

22914

Issue Date

2021-04-01

Receive Date

2020-12-30

Publish Date

2021-04-01

Page Start

1,859

Page End

1,865

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 4_Pages 1859-1865.pdf

PDF . 319.2kB

Link

https://ejchem.journals.ekb.eg/article_140621.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=140621

Order

19

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

RANTES as a novel biomarker for atherogenic dyslipidemia and metabolic disturbances in patients with Type 2 Diabetes

Details

Type

Article

Created At

22 Jan 2023