Beta
ManageSearchChatDiscover
135507

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Croton tiglium seeds and Moringa oleifera leaves extracts are rich in phytoconstituents with the antioxidant efficiency which can be enhanced by incorporating silver nanoparticles (Ag-NPs). The present study was designed to compare the effect of C. tiglium seeds and M. oleifera leaves nano-extracts on brain tissues of murine models.
During the current study, acetylcholine esterase (ACHE), β-amyloid (Aβ) content and inflammatory markers were measured in brain tissues. Moreover, native protein, lipoprotein and isoenzymes patterns were electrophoretically detected. Also, the interferon-gamma (INF-γ) receptor protein was studied by molecular dynamic simulation to evaluate the significant alterations on brain tissues.
It was found that ACHE, Aβ contents and inflammatory markers increased in the C. tiglium nano-extract treated group at a dose of 6.5 ml/kg. Furthermore, it caused qualitative electrophoretic abnormalities represented by lowering similarity index (SI) values. Also, the resides range 119~127 represent the most reactive and flexible site in INF-γ receptor protein. On the other hand, it was shown that no significant differences were induced by silver M. oleifera nano-extract.

DOI

10.21608/ejchem.2021.53777.3113

Keywords

Croton tiglium Seeds, Moringa oleifera leaves, Nanotechnology, Electrophoresis, Molecular Dynamic Modeling

Authors

First Name

Wael

Last Name

Aboulthana

MiddleName

M.

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, 33 Bohouth Street, Dokki, Giza, Egypt (Affiliation ID: 60014618).

Email

wmkamel83@hotmail.com

City

Dokki, Giza

Orcid

0000-0002-4848-0731

First Name

Ahmed

Last Name

Youssef

MiddleName

M.

Affiliation

Packaging Materials Department, National Research Centre, 33 Bohouth St., P.O. 12622, Dokki, Giza, Egypt (Affiliation ID: 60014618).

Email

drahmadyoussef1977@gmail.com

City

Dokki, Giza

Orcid

0000-0002-6501-6658

First Name

Mohamed

Last Name

Seif

MiddleName

M.

Affiliation

Toxicology and Food Contaminants Department, Food Industry and Nutrition Division, National Research Center

Email

seif.eg@gmail.com

City

Dokki, Giza

Orcid

0000-0002-0131-003

First Name

Noha

Last Name

Osman

MiddleName

M.

Affiliation

Cell Biology Department, Genetic Engineering and Biotechnology Division, National Research Centre, 33 Bohouth St., P.O. 12622, Dokki, Giza, Egypt (Affiliation ID: 60014618).

Email

osman.noha@yahoo.com

City

Dokki, Giza

Orcid

-

First Name

Ram

Last Name

Sahu

MiddleName

Kumar

Affiliation

University College of Pharmacy, Pt. Deendayal Upadhyay Memorial Health Sciences and Ayush University of Chhattisgarh, Raipur (C.G.), India.

Email

ramsahu79@yahoo.co.in

City

India

Orcid

0000-0001-5671-6591

First Name

Mohamed

Last Name

Ismael

MiddleName

-

Affiliation

Energy and Environmental Sciences Laboratory, Chemistry Department, Faculty of Science, Sohag University, Egypt.

Email

usa_moh2000@yahoo.com

City

Sohag, Egypt

Orcid

-

First Name

Hatim

Last Name

El-Baz

MiddleName

A.

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, 33 Bohouth Street, Dokki, Giza, Egypt (Affiliation ID: 60014618).

Email

helbaz78@yahoo.com

City

Dokki, Giza

Orcid

0000-0003-3156-7870

First Name

Nagwa

Last Name

Omar

MiddleName

I.

Affiliation

Biochemistry Department, Genetic Engineering and Biotechnology Research Division, National Research Centre, 33 Bohouth Street, Dokki, Giza, Egypt affiliation ID: 60014618.

Email

nagwam2012@gmail.com

City

Dokki, Giza

Orcid

-

Volume

64

Article Issue

4

Related Issue

22914

Issue Date

2021-04-01

Receive Date

2020-12-15

Publish Date

2021-04-01

Page Start

1,709

Page End

1,731

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 4_Pages 1709-1731.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_135507.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=135507

Order

6

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

Details

Type

Article

Created At

22 Jan 2023