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128408

Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Analytical chemistry

Abstract

Damsin and neoambrosin are two important anticancer phytopharmaceuticals of Ambrosia maritima (Damsissa). Despite their importance, no report has yet discussed their extraction from plants on lab or industrial scales. Consequently, the present article aims to develop an ultrasonic-assisted extraction (UAE) model for their extraction on the lab scale. Box-Behnken model was applied to investigate the effects of ethanol strength (X1: 40-100%), drug solvent ratio (DSR, X2: 1:20-1:60), and time (X3: 30-90 min) on the yield of damsin and neoambrosin in damsissa extract. Surprisingly, only ethanol strength was the significant factor in damsin yield with an optimum value of 65%. Time and DSR played no significant roles in damsin content. No statistically significant model could be deduced for neoambrosin. The model is a preliminary step to elucidate factors affecting the UAE of sesquiterpene lactones from plants and a preamble for its large scale green extraction.

DOI

10.21608/ejchem.2020.47736.2989

Keywords

Damsin, Neoambrosin, Ultrasonic-assisted extraction, response Surface method, sesquiterpene lactones, Ambrosia

Authors

First Name

Shymaa

Last Name

Ali Abdeldayem

MiddleName

Ibrahim

Affiliation

Pharmacognosy,pharmacy,Cairo university, Cairo, Egypt

Email

shymaa.aly@pharma.cu.edu.eg

City

Cairo

Orcid

0001-8152-6781

First Name

Mohammed

Last Name

Khalil

MiddleName

Nabil Ahmed

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University. Pharmacognosy department, faculty of pharmacy, Heliopolis University for Sustainable Development

Email

mohamed.nabil@pharma.cu.edu.eg

City

Cairo

Orcid

0000-0002-1134-1164

First Name

Enas

Last Name

Abdelrahman

MiddleName

Hussein

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University

Email

enas.abdelrahman@pharma.cu.edu.eg

City

Cairo

Orcid

0000-0001-5062-8160

First Name

Hamida

Last Name

El-Gohary

MiddleName

Mohamed

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University

Email

h.elgohary@hotmail.com

City

Cairo

Orcid

0000-0001-7367-3343

First Name

Ali

Last Name

Yehia

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University. Chemistry Department, School of Pharmacy and Pharmaceutical Industries, Badr University in Cairo (BUC)

Email

ali.yehia@pharma.cu.edu.eg

City

Cairo

Orcid

0000-0003-4942-1474

Volume

64

Article Issue

3

Related Issue

21851

Issue Date

2021-03-01

Receive Date

2020-11-01

Publish Date

2021-03-01

Page Start

1,433

Page End

1,439

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 64_Issue 3_Pages 1433-1439.pdf

PDF . 583.6kB

Link

https://ejchem.journals.ekb.eg/article_128408.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=128408

Order

32

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Ultrasound-Assisted Extraction of Damsin and Neoambrosin from Ambrosia maritima: Optimization Using Response Surface Methodology

Details

Type

Article

Created At

22 Jan 2023