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109398

Formulation of Mouth Dissolving Strips of Metoprolol Succinate Using Locust Bean Gum

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The current project was carried out to investigate the use of locust bean gum as a film forming agent in the development of fast dissolving oral strips that can be utilized for the drug administration in urgent situations such as convulsive seizures, hypertension and dysphasia. Oral strips of locust bean gum were formulated using solvent casting method containing metoprolol succinate as model drug. (T1- T9) placebo films were formulated initially using different concentrations of locust bean gum to assess the film forming ability of the locust bean gum. Crospovidone and PEG-200 were used as disintegrating agent and plasticizer respectively. Stability against moisture was improved by addition of beeswax. Formulated films (T1-T9) were evaluated for their appearance, film forming capacity, moisture permeability, weight variation and thickness. Placebo film formulations T4 and T6 consisting of locust bean gum (0.6 gm), beeswax (0.1 gm) and crospovidone (4%), 0.3 and 0.9 ml of PEG-200 respectively were selected for drug loading. Drug loaded films (F1 and F2) were characterised for parameters such as weight variation, film thickness, folding endurance, drug content uniformity, in vitro disintegration time, in vitro drug release, tensile strength and surface pH. Composition F2 comprising of locust bean gum (0.6 gm) and 0.9 ml of PEG- 200 was chosen as optimized formulation. Stability studies of optimized drug loaded formulation was done as per ICH guidelines of stability. Locust bean gum appears as a good alternative over the various synthetic polymers utilized in the formulation and development of oral strips/ films.

DOI

10.21608/ejchem.2020.38329.2789

Keywords

Locust Bean, Oral fast Dissolving Film/ strips, Metoprolol succinate

Authors

First Name

Rajni

Last Name

Bala

MiddleName

-

Affiliation

Chitkara college of Pharmacy Chitkara University Punjab

Email

rajni.bala@chitkara.edu.in

City

-

Orcid

-

First Name

Reecha

Last Name

Madaan

MiddleName

-

Affiliation

Chitkara College of Pharmacy, Chitkara University, Punjab India

Email

reecha.madan@chitkara.edu.in

City

-

Orcid

0000-0002-4362-0272

First Name

Radha

Last Name

Gupta

MiddleName

-

Affiliation

Chitkara College of Pharmacy, Chitkara University, Punjab, India

Email

gupta.radha255@gmail.com

City

-

Orcid

-

First Name

Rakesh

Last Name

Chawla

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot

Email

rchawlapharma@yahoo.com

City

-

Orcid

-

First Name

Ujjwal

Last Name

Sahoo

MiddleName

-

Affiliation

Dr. B C Roy College of PHARMACY and AHS

Email

sahoo.devurb@gmail.com

City

-

Orcid

-

Volume

64

Article Issue

1

Related Issue

19680

Issue Date

2021-01-01

Receive Date

2020-08-07

Publish Date

2021-01-01

Page Start

187

Page End

192

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_109398.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=109398

Order

19

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Formulation of Mouth Dissolving Strips of Metoprolol Succinate Using Locust Bean Gum

Details

Type

Article

Created At

22 Jan 2023