The redox behavior of copper sulfate in absence and presence of Amoxicillin was studied at two different temperatures (288.15 and 298.15)K. The redox behavior was studied in 0.1 M HCl electrolyte, potential range from (1.5 to -1.5)V. The copper ions concentration is small ones ranging from (3.3×10-4 to 1.67×10-3)M. Only one reduction and one oxidation peaks are obtained in our results indicating the reduction and oxidation of the divalent copper ions to the zero valent copper metal. All the solvation cyclic voltammetry parameters were evaluated at the two temperatures used and their values were discussed for cupric ions in presence and absence of Amoxicillin. Also, the thermodynamic parameters for the interaction of copper ions with Amoxicillin as stability constant, Gibbs free energies, enthalpies and entropies of interaction were calculated. The thermodynamic parameters indicate that the reaction between cupric ions and Amoxicillin is chemical reaction (high negative Gibbs free energies values), good spontaneous (positive entropies) and endothermic chemical reaction (valuable positive values). Energy values of interaction between Amx and 2hg6 which obtained by molecular docking calculations indicate that Amx has an anticancer activity for liver cancer treatment