Water Desalination is becoming an issue for saving the required potable and drinking water due to shrinkage of pure water. Thus, this work deals with antifouling membrane preparation using poly meric compounds of Polyethersulfone/ Polyvinylalcohol (PES/PVA) with nanomaterials to produce antifouling membrane for water desalination. The PES membrane has prepared by phase inversion process followed by different coating ways. The coating with PVA provided the highest hydrophilic surface. The characterization of prepared membranes was carried out using various analysis methods such as scanning electron microscopy (SEM), mechanical properties, porosity and contact angle. The pore size distribution of prepared membranes was determined using the Brunauer-Emmett-Teller (BET) method. The result showed that the best membrane performance was membrane which has a coating with PVA layer, where rejection reached to 99 %, 95% and 88% as a function of concentration 500, 1500, and 3000 ppm respectively, while the permeate flux reached to 48.4 L/m2.h, 32.3 L/m2.h and 21.5 L/m2.h as a function of concentration 500, 1500, and 3000 ppm respectively.