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85813

Design, synthesis and antibacterial activity of N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide as Nitrofurantoin® analogues

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Nitrofurantoin® is an effective drug and used for treating urinary infectious diseases. A series of nitrofurantoin® analogues bearing furan and pyrazole scaffolds as N-aryl-3-(arylamino)-5-(((5-substituted furan-2-yl)methylene)amino)-1H-pyrazole-4-carboxamide (7a-g and 9a-f) were designed and synthesized by the condensation of 5-aminopyrazole with 5-nitrofuran-2-carbaldehyde (6) or 5-methylfuran-2-carbaldehyde (8) for evaluation of their antibacterial properties against Gram +ve and Gram -ve bacteria then comparing with nitrofurantoin® as standard drug.

DOI

10.21608/ejchem.2020.26158.2525

Keywords

Furan scaffold, Pyrazole scaffold, 5-Aminopyrazole, Nitrofurantoin® analogues, Antibacterial

Authors

First Name

Ashraf

Last Name

Hassan

MiddleName

S.

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt

Email

ashraf_salmoon@yahoo.com

City

-

Orcid

0000-0002-4771-716X

First Name

Gaber

Last Name

O. Moustafa

MiddleName

-

Affiliation

Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt. Nahda University, New Beni-Sueif City, Postal code (62521), Beni-Sueif, Egypt.

Email

gosman79@gmail.com

City

-

Orcid

-

First Name

Nesrin

Last Name

Morsy

MiddleName

Mahmoud

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Dokki 12622, Egypt

Email

nesrinmorsy@yahoo.com

City

-

Orcid

0000-0003-3636-1767

First Name

Amr

Last Name

Abdou

MiddleName

M.

Affiliation

Department of Microbiology and Immunology, National Research Centre 12622 Dokki, Giza, Egypt

Email

amrkheir@yahoo.com

City

-

Orcid

-

First Name

Taghrid

Last Name

Hafez

MiddleName

S.

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622 Cairo, Egypt

Email

taghridshafez@yahoo.com

City

-

Orcid

0000-0002-1958-3520

Volume

63

Article Issue

11

Related Issue

18119

Issue Date

2020-11-01

Receive Date

2020-03-19

Publish Date

2020-11-01

Page Start

4,469

Page End

4,481

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 11_Pages 4469-4481.pdf

PDF . 495.5kB

Link

https://ejchem.journals.ekb.eg/article_85813.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=85813

Order

27

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023