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78942

Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

In this study, a new series of anthracene-9-sulfonyl derivatives incorporated with different heterocyclic moieties were synthesized and screened for their in vitro anticancer activity against colon carcinoma cell lines (HCT-116), hepatic carcinoma cell lines (HepG 2) and breast carcinoma cell lines (MCF-7). Among them, compound 4-acetylphenyl anthracene-9-sulfonate (8) showed selective high cytotoxic activity over colon carcinoma cell lines (HCT-116), also compounds 2-(anthracen-9-ylsulfonyl)malononitrile (7), N-(4-fluorophenyl)anthracene-9-sulfonamide (5b) and N-((1H-benzo[d]imidazol-2-yl)methyl)anthracene-9-sulfonamide (10) showed the significant selective cytotoxic effect over breast carcinoma cell lines (MCF-7). All the compounds are subjected to explore their safety on normal human skin cell lines (BJ-1), the results revealed that all the compounds are safe and have insignificant weak cytotoxicity over normal human cells.

DOI

10.21608/ejchem.2020.24843.2473

Keywords

anthracene, 9, sulfonyl. Anticancer. HCT, 116 cells. HepG 2 cells. MCF, 7 cells

Authors

First Name

Walaa

Last Name

Salah Goda Elserwy

MiddleName

-

Affiliation

Pharmaceutical Industries Research division Therapeutical Chemistry Department National Research Centre

Email

walaasalah16@yahoo.com

City

-

Orcid

0000-0002-0400-4637

First Name

neama

Last Name

mohammed

MiddleName

-

Affiliation

2Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt, 12622.

Email

neamanrc@yahoo.com

City

-

Orcid

0000-0003-1221-9926

First Name

Emad

Last Name

Kassem

MiddleName

-

Affiliation

Department of Therapeutic Chemistry, National Research Centre, Dokki 12622, Giza, Egypt,

Email

emadkassem@hotmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Mounier

MiddleName

-

Affiliation

Pharmaceutical and Drug Industries Research Division, Department of Pharmacognosy, National Research Centre, Giza, Egypt

Email

marwa_m3@yahoo.com

City

-

Orcid

-

First Name

Weam

Last Name

Salah Goda Elserwy

MiddleName

-

Affiliation

Department Of Microbial and Natural Products chemistry National Research Centre

Email

awab_13@yahoo.com

City

-

Orcid

0000-0003-1757-1742

Volume

63

Article Issue

11

Related Issue

18119

Issue Date

2020-11-01

Receive Date

2020-02-28

Publish Date

2020-11-01

Page Start

4,217

Page End

4,225

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 11_Pages 4217-4225.pdf

PDF . 475.2kB

Link

https://ejchem.journals.ekb.eg/article_78942.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=78942

Order

6

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Novel anthracene-9-sulfonyl derivatives as anticancer agents: synthesis and in vitro biological evaluation

Details

Type

Article

Created At

22 Jan 2023