Emulsion stability of oil based drilling fluids is a critical parameter for ultimate fluid performance, this property is controlled using a powerful emulsifiers. Good formulations of drilling fluid properties are required in the drilling operations which can be achieved by selection of adequate additives. The aim of this work is based on two parts; The first part is to enhance emulsion stability of oil based drilling fluids by series of nonionic secondary emulsifiers developed by esterification & amidation (MEAO, DEAO, DETAOA, DETADS, TEAOE and EGOE ) reactions from local materials. The chemical structure for the prepared secondary emulsifiers was elucidated using elemental analysis and FTIR. The second part is studying the mud stability by the secondary synthesized emulsifiers in presences of CuO nanoparticles. Besides, the rheological behavior, filtration loss and gel strength were investigated. The results revealed that, the maximum emulsion stability was achieved with the secondary emulsifiers (DEAO and DETAOA), the addition of CuO nanoparticles to the oil base mud pronounced extremely stability integrated with all mud properties as described in the text.