This work is concerned with studying the effect of Green synthesized Silver Nanoparticles (GSNPs) on the mosquito larvae of Culex pipiens. The lethal concentration Lc10, Lc50 and Lc90 were obtained from the established regression log concentrate-response lines after 24 hours of exposure. Results implied significant increasing mortality rate upon increasing the lethal concentrations of GSNPs which recorded 0.576 ppm, 1.719 ppm and 5.129 ppm for Lc10, LC50, and Lc90 respectively. For investigating the root cause of mortality, data indicated that there was a significant increase of lipid peroxidation level in tissue homogenates of larvae previously treated with the increasing of above mentioned lethal concentrations of GSNPs, which recorded 17.25 nmol/g.tissue, 18.0 nmol/g.tissue and 25.0 nmol/g.tissue for LC10, LC50, and LC90 respectively, compared to control sample which recorded 16.0 nmol/g. tissue. At the meantime, data also revealed a significant increase in levels of total protein, albumin and globulin levels in tissue homogenates of larvae previously treated with the increasing of above mentioned lethal concentrations of GSNPs , which recorded, 0.231 g/dl , 0.109 g/dl and 0.122 g/dl for Lc10, 0.735 g/dl, 0.115 g/dl and 0.62 g/dl for Lc50, 0.93 g/dl ,0.125 g/dl and 0.805 g/dl for Lc90 for total protein, albumin and globulin, respectively, compared to control samples which recorded 0.21 g/dl , 0.089 g/dl and 0.121 g/dl, respectively.