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88183

Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcon

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Some of Schiff base derivatives were separated by condensing 3-formyl-2-quinolinone with various primary amine derivatives in ethanol, in which water is expelled. Moreover, substituted acryloylphenyliminomethylquinolinone chalcone derivatives were prepared by the process of condensation reaction of aldehyde derivatives with 3-acetylphenylquinolinone in dilute solution of ethanolic sodium hydroxide via Claisen-Schmidt condensation method. Cyclization reaction of the quinolinone chalcones with malononitrile, phenylhydrazine, urea and thiourea were also investigated. The structures of these compounds have been elucidated on the bases of spectral data. The novel products were also evaluated for their antimicrobial activity.

DOI

10.21608/ejchem.2020.27574.2580

Keywords

2-Oxo-3-formaldehyde quinoline, Primary amines, aldehydes, Claisen-Schmidt condensation, Molecular docking, antimicrobial evaluation

Authors

First Name

sohier

Last Name

maigali

MiddleName

-

Affiliation

National Research center

Email

s_maigali@yahoo.com

City

-

Orcid

-

First Name

hanaa

Last Name

tawfik

MiddleName

awad

Affiliation

1Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Giza, Egypt.

Email

hanaa_tawfik@hotmail.com

City

CAIRO

Orcid

-

First Name

Mansoura

Last Name

Ali

MiddleName

-

Affiliation

National Research Centre,Dept. of Organometallic and Organometalloid Chemisry

Email

mansouraali2000@yahoo.com

City

-

Orcid

-

First Name

Fouad

Last Name

Soliman

MiddleName

-

Affiliation

Organometallic and organometalloid chemistry dept

Email

solimanfma2@yahoo.com

City

-

Orcid

-

First Name

Maysa

Last Name

Mohramb

MiddleName

E.

Affiliation

a Department of Organometallic and Organometalloid Chemistry, b Microbial Chemistry Department, National Research Centre,

Email

maysa_nrc@live.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

dondeti

MiddleName

Fathy

Affiliation

National Research Centre

Email

mahmoud_dondeti@yahoo.com

City

-

Orcid

-

Volume

63

Article Issue

10

Related Issue

17778

Issue Date

2020-10-01

Receive Date

2020-04-10

Publish Date

2020-10-01

Page Start

3,903

Page End

3,914

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 10_Pages 3903-3914.pdf

PDF . 530.6kB

Link

https://ejchem.journals.ekb.eg/article_88183.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=88183

Order

30

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Molecular Docking and Antimicrobial Activities of 3-Formyl-2- (1H)quinolinone Schiff Base Derivatives and 3-(((3-Acetylphenyl)imino)- methyl)quinolin-2-(1H)-one Chalcone Derivatives

Details

Type

Article

Created At

22 Jan 2023