The current work reports the synthesized and biological evaluation of 6-methoxy-2-amino benzothiazole (A1), which was prepared via reaction p-Ansidine with ammonium thiocyanate followed by the oxidative ring closure of the resultant thiourea with a catalytic amount of bromine, in the alkaline medium.
The resulting compound(A1) underwent condensation reactions with various kinds of aldehydes to produce Hydrazones (A3a- d).
6-methoxy2-hydrazinobenzothiazole (A2) was prepared through the reaction of the compound (A1) with 99.9 % hydrazine hydrate in the presence of concentrated HCl and ethylene glycol solution.
After that, the compound (A2) was reacted with ethyl acetoacetate in alcohol to yield corresponding pyrazole-6-methoxybenzothiazole (A4).
Moreover, the compound (A2) was reacted with 4- substituted aromatic aldehydes in absolute ethanol to create Hydrazones (A5a-d). Synthesized compounds were investigated as anti-bacterial activity against five microorganisms:(Gram-positive: Bacillus subtilis & Staphylococcus aurea). (Gram-negative: Pseudomonas aeruginous Escherichia coli and Enterobacter)