Beta
76508

Saraca indica L. leaves, Phytochemical, invitro Antioxidant and Cytotoxic Activities

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Saraca indica L. (Saraca asoca) is reported for its important biological benefits in Indian folk medicine. The powdered leaves were extracted with 70% ethanol to obtain total ethanol extract(TEE) that was successively fractionated to get petroleum ether(pet. ether),chloroform(CHCl3), ethyl acetate (EtOAc) and methanol extracts.The antioxidant activityof TEE by three methods of assay, as well as,the antioxidant activity of TEE and successive extracts by DPPHmethod at two dose were done.Total phenolics and total flavonoids content of the plant were determined. The cytotoxic evaluation revealed that EtOAc extract exhibited activity against HCT-116 andMCF-7, Hela& HEPG-2 . GC/MS analysis of the unasponifiable(USF) and saponifiable (SF)fractions of the non-polar extractwas carried out. 34 Compounds with phytol, dodecane, BHT and α -amyrin as the major compoundsin the USFand 25 compounds with methyl palmitate&Methyl-9, 12,15- octadecatrienoate as major compounds in the SF were identified. Fifteen phenolic compounds were detected in HPLC analysis of EtOAcextract as well as six phenolic compounds were isolated and identified for the first time from the same extract they were; gallic acid, methylgallate, rutin, quercetin -3-O-rhamnoside, quercetin and kaempeferol

DOI

10.21608/ejchem.2020.23139.2371

Keywords

Saraca indica L, antioxidant, Cytotoxic activities, Total phenolic, Total flavonoids, Unsaponifiable, Saponifiable fractions

Authors

First Name

wedian

Last Name

Ashour

MiddleName

-

Affiliation

Department of Pharmacognosy, National Research Centre

Email

dr.wedian.ashour@gmail.com

City

-

Orcid

-

First Name

Reda

Last Name

Mohammed

MiddleName

-

Affiliation

Pharmacognosy Dept. , National Research Centre; 33-Elbohouth St, (Former El-Tahrir St.), Dokki – Giza-Egypt. P.O.12622, ID: 60014618

Email

reda_sayed2008@yahoo.com

City

-

Orcid

0000-0002-8838-9027

First Name

Aisha

Last Name

Abou Zeid

MiddleName

H.

Affiliation

Pharmacognosy Department, Pharmaceutical and Drug Industry, National Research Center

Email

abouzeida@yahoo.co.uk

City

Cairo

Orcid

0000-0001-7807-9722

First Name

Omar

Last Name

Sabry

MiddleName

-

Affiliation

pharmacognosy Dept. Faculty of pharmacy Cairo university

Email

omar.sabry@ca.edu.eg

City

-

Orcid

-

First Name

Seham

Last Name

El Hawary

MiddleName

Salah Eldin

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University

Email

seham.elhawary@yahoo.com

City

Cairo

Orcid

0000-0002-6823

Volume

63

Article Issue

10

Related Issue

17778

Issue Date

2020-10-01

Receive Date

2020-01-28

Publish Date

2020-10-01

Page Start

3,779

Page End

3,790

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_76508.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=76508

Order

17

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Saraca indica L. leaves, Phytochemical, invitro Antioxidant and Cytotoxic Activities

Details

Type

Article

Created At

22 Jan 2023