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74838

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Abstract:
A new series of 2-phenyl-1,8-naphthyridine derivatives were synthesized via traditional heating and under ultrasonic irradiation to run out comparative study and confirm the utility of the green chemistry in organic synthesis. An improvement in the rates and yields were observed upon carrying out the reactions under environmentally benign protocol. The newly produced compounds were scanned in vitro for their adverse activity on HepG2 (Human liver) carcinoma cell lines. Results revealed that the tested compounds possess an inhibitory effect on the growth of HepG2 carcinoma cells. The naphthyridinyl pyridine derivatives 4c and 5c showed significant cytotoxic activity. The oxo-pyridine derivative4c was more potent than the reference drug doxorubicin (DOX), while the imino-pyridine derivative 5c showed slight reduction in the potency. On the other hand, Mannich bases (2a,c,d,e) showed good activity and the styryl derivatives (6b-d) showed moderate activity when compared to (DOX).

DOI

10.21608/ejchem.2020.24391.2451

Keywords

ultrasound irradiations, 1,8-naphthyridine, mannich bases, styryl compounds, Pyridine, cytotoxic

Authors

First Name

Nesreen S.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Division, National Research Center,Cairo, Egypt

Email

nesreen69eg@yahoo.com

City

-

Orcid

0000-0001-9136-9986

First Name

Eman S.

Last Name

Alsulami

MiddleName

-

Affiliation

Chemistry Dept., Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Email

emyyyy-emoo@hotmail.com

City

-

Orcid

-

First Name

Khadija O.

Last Name

Badahdah

MiddleName

-

Affiliation

Chemistry Dept., Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Email

kbadahdah@yahoo.com

City

-

Orcid

-

First Name

Zahra M.

Last Name

Al-Amshany

MiddleName

-

Affiliation

Chemistry Dept., Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Email

zalamshany@hotmail.com

City

-

Orcid

-

First Name

Mogedda E.

Last Name

Haiba

MiddleName

-

Affiliation

Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Center, El Buhouth Street, Dokki, Cairo, 12622, Egypt

Email

mogedda.haiba@yahoo.com

City

-

Orcid

-

Volume

63

Article Issue

10

Related Issue

17778

Issue Date

2020-10-01

Receive Date

2020-02-21

Publish Date

2020-10-01

Page Start

3,757

Page End

3,766

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 10_Pages 3757-3766.pdf

PDF . 722.8kB

Link

https://ejchem.journals.ekb.eg/article_74838.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=74838

Order

15

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

Details

Type

Article

Created At

22 Jan 2023