The purpose of the present study is to harness the natural plant extracts to print and treatment the cotton fabrics and its blends. This study reports the impart Ultra Violet protection factor (UPF) to woven fabrics such as cotton and its blend which printed with colorants of Melia azedarach extract. The results showed a difference in the functional groups between the printed and unprinted samples, which indicates that the new functional groups are specific to the treatment materials used in printing paste . The results also indicated that the UPF values for the printed samples are much higher than unprinted one, and some of these values are higher than the specifications limit for the UPF tests. Also results showed that the K/S values of printed samples are higher than unprinted samples, irrespective of the nature of the fabric used especially in the case of samples treated with citric acid as mordant in which it shows a direct increase directly proportional to the increased concentration. The results also indicated that the air permeability of the printed samples is lower than that of the unprinted samples as a result of the treatment operations. While under investigation Colour fastness to rubbing, washing, perspiration and light showed values were very good to excellent In all samples and at all concentrations.