This study deals with the utilization of silicon dioxide nanoparticles (SiO2 NPs) to treatment of wool and polyamide 6 fabrics. The fabrics treated with different concentrations of SiO2 NPs (5- 20 g/l) using pad-dry- cure technique. The size of nano silicon dioxide particles measured with TEM. The surface morphology and surface chemical elements of treated and untreated fabrics were characterized through high-resolution Scanning Electron Microscopy (SEM) and Dispersive X-Ray spectroscopy (EDX), respectively. The untreated and treated wool and polyamide fabrics were characterized by FTIR. The effect of the treatment on dyability of both wool and polyamide 6 fabrics using different dyestuffs such as acid, basic and direct dyes is studied with applying innovation technique to save energy, water and time. For comparison, the same dyeing technique was carried out by using conventional heating technique. The colour strength and the fastness tests of the untreated and treated wool and polyamide 6 fabrics were evaluated. The effects of SiO2 NPs on the physical and multifunctional properties of the treated sample such as weight, thickness, UPF, antibacterial activity and moisture regain % were determined. The obtained results indicate that the optimization of dyeing process parameters as well as optimized treatment of both wool and polyamide fabrics with SiO2 NPs has a significant influence on the obtained shades and fastness properties.