Cancer is a serious concern right away which severely affects the mankind. Recently, the centre of interest of pharmaceutical industry is to develop newer drug molecules with very less or no toxicity to prevent and cure this life-threatening disease. Nature is the origin of remedies for human. Natural therapeutic agents brought a great change in recent drug market, as these are simple, safer, eco-friendly, low-cost, and less toxic in respect to commonly using drugs. Natural anticancer agents are selective in their functions and targetfully act on tumor cells without having any effect on normal cells. Cancer is a complex phenomenon which requires many signaling pathways. Natural therapeutic agents are the appropriate candidates to develop anticancer drug on account of their pleiotropic actions on target events with diverse manners. In this review we have collected a basket, flooded with latest information (2010-2020) on prevention and treatment of cancer with several products from nature, such as phytohemical (artemisinin, parthenolide, thapsigargin, curcumin, resveratrol, quercetin, coumarin, calcitriol, capsaicin, fisetin, evodiamine, boswellic acid, betulinic acid, deoxyelephantopin), plant (Rosmarinus officinalis L., Aloe vera, Olea europaea), functional foods (pomegranate, mango, amla, garlic, ginger, broccoli, mushroom, green tea, coffee, honey), textile and marine product based on their mechanism of action.