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72025

Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

In this present work, synthesized a novel derivatives of bis-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds 4a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, 1HNMR, 13CNMR, and elemental analysis. The new compounds have been screened as anti-bacterial activity

DOI

10.21608/ejchem.2020.21641.2289

Keywords

Synthesis, bis Chalcones, ethylcyanoacetate, cyanopyridine and antimicrobial Activity

Authors

First Name

Amira A.

Last Name

Ghoneim

MiddleName

-

Affiliation

Chemistry Department, College of Science, Jouf University, P. O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia. Tel.: 00966541609390. , Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt.

Email

aa_amiraatef@yahoo.com

City

Sakaka

Orcid

-

First Name

Rehab M.

Last Name

Elbargisy

MiddleName

-

Affiliation

Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, AlJouf, Saudi Arabia, Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Email

-

City

-

Orcid

-

First Name

Afaf

Last Name

Manoer

MiddleName

-

Affiliation

Chemistry Department, College of Science, Jouf University, P. O. Box 2014, Sakaka, Aljouf, Kingdom of Saudi Arabia. Tel.: 00966541609390

Email

-

City

-

Orcid

-

Volume

63

Article Issue

8

Related Issue

10594

Issue Date

2020-08-01

Receive Date

2019-12-29

Publish Date

2020-08-01

Page Start

2,901

Page End

2,910

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 8_Pages 2901-2910.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_72025.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=72025

Order

9

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity

Details

Type

Article

Created At

22 Jan 2023