Weight loss method was used to investigate the inhibition and adsorption behavior of phenylphrine drug for aluminum2024 alloy corrosion in 1 M acidic chloride solution at 293-303 Kelvin. Results obtained indicate that phenylphrine act as inhibitor for Al 2024 alloy in molar hydrochloric acid solution. Increasing both phenylphrine concentration and temperature lead to increase the inhibition efficiency, which is indicating the chemisorption mechanism. The adsorption of the phenylphrine onto the Al 2024 alloy surface follow Langmuir adsorption isotherm model. The mechanism of inhibition was additionally proved by the activation parameters results that obtained from the experimental data. SEM image shows a smoothed surface of Al 2024 alloy in the presence of phenylphrine in acidic solution. Quantum chemical calculation was used to correlate inhibition efficiencies data of phenylphrine with its electronic structural parameters. Theoretical calculations support the experimental results and elucidate working mechanisms.