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71917

Synthesis of new (±)-1-(4-(3-fluorobenzyloxy)pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives via Click reaction and study of anti-cancer activity against HCT 116, MDA-MB231, Mia-PaCa2 Cell lines

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

A series of 16 new (±) -1-(4-(3-fluorobenzyloxy) pyrrolidin-3-yl)-4-phenyl-1H-1,2,3-triazole derivatives were synthesized from 2,5-dihydro-1H-pyrrole. Sixteen compounds are well characterized by their 1H NMR, 13C NMR and mass spectral data. Anticancer activities of these compounds were tested against HCT 116, MDA-MB231, Mia-PaCa2 cancer cell lines. Among these series of compounds, 8b exhibited highest activity with IC50 of 42.5 µg/ mL against MDA-MB231 cell line. The compound 8o and 8n showed moderate activity with IC50 of 64.3 µg/ mL and 68.4 µg/ mL against HCT -116 and Mia-PaCa2 cancer cell lines respectively.

DOI

10.21608/ejchem.2019.16652.2014

Keywords

1, 2, 3-Triazole, Anticancer, MDA-MB231, HCT 116, Mia-PaCa2

Authors

First Name

HARI BABU

Last Name

Bollikolla

MiddleName

-

Affiliation

DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA

Email

dr.b.haribabu@gmail.com

City

GUNTUR

Orcid

-

First Name

Ravi Kumar

Last Name

g

MiddleName

-

Affiliation

Department of Chemistry, Government Degree College, Husnabad-505467, Telangana, India.

Email

ravig333@gmail.com

City

warangal

Orcid

-

First Name

s n murthy

Last Name

b

MiddleName

-

Affiliation

Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India

Email

snmurthyboddapati@gmail.com

City

-

Orcid

-

First Name

Santha Kumari

Last Name

m

MiddleName

-

Affiliation

Department of Chemistry, Government Degree College for Women (A), Srikakulam-532001, Andhra Pradesh, India

Email

santhijosh@gmail.com

City

srikakulam

Orcid

-

Volume

63

Article Issue

8

Related Issue

10594

Issue Date

2020-08-01

Receive Date

2019-09-06

Publish Date

2020-08-01

Page Start

2,813

Page End

2,825

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 8_Pages 2813-2825.pdf

PDF . 1.1MB

Link

https://ejchem.journals.ekb.eg/article_71917.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=71917

Order

2

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023