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Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

This study aimed to synthesize AgNPs using Chenopodium murale extract (CME), to evaluate the antioxidant activity of the Chenopodium murale essential oil (CMEO) and the protective role against nephrotoxicity of AgNPs. Seven groups of female Sprague-Dawley rats were treated orally for 21 days included the control group, AgNPs-treated groups (25 or 50 mg/kg b.w), CMEO-treated groups (0.5 or 1 mg/kg b.w) and AgNPs plus CMEO-treated groups. The synthesized AgNPs were 30-50 nm in size. CMEO is rich in total phenolic and flavoniods and showed high antioxidant and radicals scavenging activity in vitro. AgNPs disturbed kidney function, decreased the antioxidant enzymes, increased serum electrolytes, TNF-α, MDA and NO, up-regulated Bcl-2, down-regulated Bax and P53 and induced histological changes in kidney tissue. CMEO protected the kidney against AgNPs toxicity in a dose-dependent manner. It could be concluded that AgNPs induced cytotoxicity and oxidative stress in the kidney. CMEO overcomes the nephrotoxicity and should be considered as a supplement to protect the kidney against oxidative stress.

DOI

10.21608/ejchem.2019.18341.2128

Keywords

Chenopodium murale, silver nanoparticles, Nephrotoxicity, essential oil, Oxidative Stress, genotoxicity

Authors

First Name

Mossad

Last Name

Abdel-Wahhab

MiddleName

Attia

Affiliation

Department of Food Toxicology & Contaminants. National Research Center

Email

mosaad_abdelwahhab@yahoo.com

City

Cairo

Orcid

0000-0002-7174-3341

First Name

Helmy

Last Name

Ahmed

MiddleName

M.S

Affiliation

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Cairo University

Email

helmy_ahmed@gmail.com

City

Cairo

Orcid

-

First Name

Aziza

Last Name

El-Nekeety

MiddleName

A

Affiliation

Food Toxicology & Contaminants Dept., National Research Center

Email

azaegjp@yahoo.com

City

Cairo

Orcid

-

First Name

Sekena

Last Name

Abdel-Aziem

MiddleName

H

Affiliation

Cell Biology Dept, National Research Center

Email

nadanahl@yahoo.com

City

Cairo

Orcid

-

First Name

Hafiza

Last Name

Shara

MiddleName

A.

Affiliation

Pathology Dept., National Research Center

Email

hafiza.sharaf@yahoo.com

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Abdelaziz

MiddleName

-

Affiliation

Microbial Chemistry Dept., National Research Center

Email

mohabomerna@yahoo.ca

City

Cairo

Orcid

-

First Name

Mohamed

Last Name

Sallam

MiddleName

F.

Affiliation

New Kasr Al-Ainy Hospital, Cairo

Email

mfsallam@hotmail.com

City

Cairo

Orcid

-

First Name

Fathia

Last Name

Mannaa

MiddleName

A.

Affiliation

Physiology Dept. National Research Center

Email

fathia_98@yahoo.com

City

Cairo

Orcid

-

Volume

63

Article Issue

7

Related Issue

10593

Issue Date

2020-07-01

Receive Date

2019-10-17

Publish Date

2020-07-01

Page Start

2,631

Page End

2,646

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 7_Pages 2631-2646.pdf

PDF . 1.7MB

Link

https://ejchem.journals.ekb.eg/article_66026.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=66026

Order

18

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Chenopodium Murale Essential Oil Alleviates The Genotoxicity and Oxidative Stress of Silver Nanoparticles in The Rat Kidney

Details

Type

Article

Created At

22 Jan 2023