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82063

Bezafibrate Scaffold Derived Hydrazide-Hydrazones: Synthesis and Antioxidant Activities

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

A new series of Bezafibrate derived hydrazide-hydrazone analogues were generated by using some five membered, fused heterocyclic and aromatic aldehydes. All the hydrazones were obtained in good yields from methanol at 60-80 °C for 5-8 hours stirring. Moreover, the compounds were also screened after their anti-oxidant activity potentiality at four different concentrations using DPPH method. Among these compounds, compound 6k analogue of bezafibrate was found to be the most active at all the tested concentrations (≈ 40% inhibition at 25 μg/mL ) followed by 6j (4-hydroxy, 3-methoxy 5-bromo analogue ≈ 35% at 25 μg/mL) compared to standard ascorbic acid (49.6% at 25 μg/mL).

DOI

10.21608/ejchem.2020.20809.2251

Keywords

Bezafibrate, Hydrazide-hydrazone, antioxidant, ascorbic acid

Authors

First Name

HARI BABU

Last Name

Bollikolla

MiddleName

-

Affiliation

DEPT. OF CHEMISTRY, ACHARYA NAGARJUNA UNIVERSITY, NNAGAR,AP-INDIA

Email

dr.b.haribabu@gmail.com

City

GUNTUR

Orcid

-

First Name

Ramya Krishna

Last Name

p

MiddleName

-

Affiliation

dept. of chemistry, acharya nagarjuna university, guntur

Email

ramyapallapati@gmail.com

City

guntur

Orcid

-

First Name

sailaja

Last Name

g

MiddleName

-

Affiliation

dept. of chemistry, Singareni Collieries Women’s Degree College, Kothagudem-507101, Telangana, India

Email

sailugugulothu007@gmail.com

City

kothagudem

Orcid

-

First Name

Umamaheswara rao

Last Name

vanga

MiddleName

-

Affiliation

Department of Microbiology, Acharya Nagarjuna University, nnagar, Guntur-522510, AP., India

Email

umrvanga@gmail.com

City

guntue

Orcid

-

Volume

63

Article Issue

7

Related Issue

10593

Issue Date

2020-07-01

Receive Date

2019-12-13

Publish Date

2020-07-01

Page Start

2,473

Page End

2,482

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 7_Pages 2473-2482.pdf

PDF . 1.2MB

Link

https://ejchem.journals.ekb.eg/article_82063.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=82063

Order

6

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023