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66025

Blending and Characterization of Gold Nanoparticles with Omega-3 Oils Induces Antidiabetic, and Antioxidant Activities in-vivo

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

The aim of the study is to explore the antidiabetic and antioxidant activities of gold nanoparticles (AuNPs) mixed with either flaxseed oil (FLO) or fish oil (FIO). A pyrolysis method was used to prepare AuNPs in oleic acid. The characteristics of the sample were determined by using the transmission electron microscope (TEM) and UV spectroscopy. Male albino rats were divided into two main groups. Group one (n=10 rats) was fed on the basic diet (serves as healthy control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1st subgroup was fed on HFD only, 2nd and 4th subgroups were fed on HFD mixed with omega-3 oils while 3rd and 5th fed on HFD+ omega-3 oils mixed with AuNPs. Results revealed that there was a significant decrease in glucose level, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid peroxidation in oils nanoparticles treated groups compared to the HFD group and a significant increase in the homeostasis model assessment of β-cell function (HOMA-β) and Glutathione (GSH). It can be concluded that AuNPs mixed omega-3 oils have more anti-diabetic, hepatic protection and antioxidant properties than omega-3 oils alone.

DOI

10.21608/ejchem.2019.18861.2159

Keywords

diabetes, Liver, Omega-3 oils, Gold nanoparticles

Authors

First Name

amira

Last Name

soliman

MiddleName

Fawzy

Affiliation

Department of nutritional chemistry and metabolism, National Nutrition Institute (NNI) - Healthy Minster, Cairo, Egypt

Email

amira_fawzy2013@yahoo.com

City

cairo

Orcid

0003-2361-4235

First Name

Mohamed

Last Name

Abdel-Rahman

MiddleName

A

Affiliation

Assistant Professor of Molecular Toxicology & Physiology of zoology, Zoology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

Email

mohamed_hassanain@science.suez.edu.eg

City

Ismailia

Orcid

0002-4876-8997

First Name

Hanaa

Last Name

Hamad

MiddleName

H

Affiliation

Professor of Environmental science for nutritional chemistry and metabolism. Department of nutritional chemistry and metabolism, National Nutrition Institute (NNI) - Healthy Minster, Cairo, Egypt.

Email

hanaa_hamad2003@yahoo.com

City

cairo

Orcid

0003-0443-0940

First Name

Elsayed

Last Name

Eltamany

MiddleName

H

Affiliation

Professor of Organic chemistry, Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.

Email

s.eltamany51@yahoo.com

City

Ismailia

Orcid

0002-1657-5234

First Name

Al-Sayed

Last Name

Al-Sherbini

MiddleName

-

Affiliation

Prof. of Photochemistry and Nano chemistry, Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science (NILES), Cairo University, Giza, Egypt.

Email

elsayed@niles.edu.eg

City

Giza

Orcid

0002-9477-3113

Volume

63

Article Issue

7

Related Issue

10593

Issue Date

2020-07-01

Receive Date

2019-10-29

Publish Date

2020-07-01

Page Start

2,419

Page End

2,433

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 7_Pages 2419-2433.pdf

PDF . 2.0MB

Link

https://ejchem.journals.ekb.eg/article_66025.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=66025

Order

2

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Blending and Characterization of Gold Nanoparticles with Omega-3 Oils Induces Antidiabetic, and Antioxidant Activities in-vivo

Details

Type

Article

Created At

22 Jan 2023