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53228

Structural Characterization, Thermal Analyses, Antiproliferative and Antimicrobial Activity of Cocaine Complexes with Mn(II) and Cu(II)

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

Inorganic chemistry

Abstract

Reaction of cocaine (Cn) with Mn(II) and Cu(II) chloride salts afforded complexes of the [M(Cn)Cl(OH2)3]Cl type which were structurally characterized by elemental analysis, conductance measurements, spectroscopic methods and mass spectroscopy. Their thermal properties were studied. The in vitro antitumor activity of the newly synthesized complexes was investigated by MTT assay on MCF-7 and HepG-2 cell lines. Both complexes exhibited promising cytotoxic activity on both cell lines with high safety on normal human cells. Their antifungal activity against Aspergillus fumigatus and Candida albicans and antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhimurium and Escherichia coli were also included.

DOI

10.21608/ejchem.2019.16748.2019

Keywords

Cocaine, Transition metal complexes, thermal analyses, Antiproliferative activity, antimicrobial activity

Authors

First Name

Nadia

Last Name

Zaki

MiddleName

G.

Affiliation

Narcotic Research Department, National Center for Social and Criminological Research (NCSCR), Giza 11561, Egypt

Email

nadiagzaki@yahoo.com

City

-

Orcid

-

First Name

Walaa

Last Name

Mahmoud

MiddleName

H.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

Email

dr.walaa@yahoo.com

City

-

Orcid

0000-0001-9187-4325

First Name

Ahmed

Last Name

El Kerdawy

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt

Email

ahmed.elkerdawy@cu.edu.eg

City

Cairo

Orcid

0000-0003-4127-9055

First Name

Abanoub

Last Name

Abdallah

MiddleName

-

Affiliation

Narcotic Research Department, National Center for Social and Criminological Research (NCSCR), Giza 11561, Egypt

Email

abanoubabdallah@gstd.sci.cu.edu.eg

City

-

Orcid

0000-0001-7735-3822

First Name

Gehad

Last Name

Mohamed

MiddleName

G.

Affiliation

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt

Email

ggenidymohamed@sci.cu.edu.eg

City

Giza

Orcid

0000-0002-1525-5271

Volume

63

Article Issue

5

Related Issue

10591

Issue Date

2020-05-01

Receive Date

2019-09-08

Publish Date

2020-05-01

Page Start

1,857

Page End

1,868

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 5_Pages 1857-1868.pdf

PDF . 1.6MB

Link

https://ejchem.journals.ekb.eg/article_53228.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=53228

Order

21

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023