Abstract
Desvenlafaxine succinate anhydrous is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) class and is used as an anti-depressive agent. This research introduces design and construction of four ion-selective carbon paste electrodes for fast and simple determination of Venlafaxine and its metabolite Desvenlafaxine in pure and in their pharmaceutical formulations. The best electrodes performance were obtained with a paste composition of 55.8% graphite, 37.2% dibutylphethalate (DBP), and 7% ion-pair for Desvenlafaxine-borate electrode DV-TPB and 46.5% graphite, 46.5% o-NPOE, and 5% ion-associate for Venlafaxine-borate electrode V-TPB, and paste composition of 46.5% graphite, 46.5% DBP, and 7% ion-associate for Desvenlafaxine–phosphotungistate electrode DV-PT and 47.5% graphite, 47.5% o-NPOE, and 5% ion-associate for venlafaxine–phosphotungistate V-PT electrode. These four electrodes illustrated fast, stable and Nernstian response over concentration range of 5.96×10-5-1.00×10-2 mol L-1 for both V-TPB and V-PT sensors and 5.66 ×10-4 -1×10-2 mol L-1 for both DV-TPB and DV-PT sensors. Validation of methods shows suitability of the sensors for application in quality control analysis of drug in pharmaceutical formulation. The obtained results were compared with official method using F- and t-tests.