This study demonstrates the utilization of phosphogypsum waste for preparation of hydroxyapatite, lanthanum-doped hydroxyapatite and cerium-doped hydroxyapatite. Three concentrations of doping for each rare earth elements were prepared (0.25, 0.5, 0.75 weight %( respectively to be used as nanoparticles fillers additive to enhance the antibacterial activity, mechanical properties and bioactivity of conventional polymethyl methacrylate based bone cements. The prepared nanoparticles fillers are incorporated manually in 20 weight % to conventional polymethyl methacrylate bone cement to achieve polymethyl methacrylate cement composites. The results revealed that cerium-doped in 0.5 weight % with hydroxyapatite / polymethyl methacrylate cement composite permits remarkable increase in antibacterial activity against Staphylococcus aureus, while preserving a reasonably adequate compressive strength, and showed much higher calcium and phosphorus ions release (P-value ≤ 0.05). Within limitation of this study, the results are indicating the opportunity of the innovative bone cement for dental and orthopedic applications.