Our goal in this article is to synthesize of four novel clioquinol (Clio) drug complexes for the Co(II), Ni(II), Cu(II) in addition to Pb(II) . On the basis of spectroscopic, magnetic, conductance and thermal studies, the complexes have been characterized. Free ligand acts as abidentate chelate with metal ions through its two atoms Oxygen in addition to nitrogen. Structural formulas for Clio complexes have chemical formulas [Co(Clio)2(H2O)2].2H2O, [Ni(Clio)2(H2O)2].H2O, [Cu(Clio)2(H2O)2].H2O in addition to [Pb(Clio)2].2H2O . The thermal decomposition of all complexes contains metal oxides as a residue in its final degradation steps. The antimicrobial activities of the complexes are in a good assessment and the synthesized complexes have a higher activity with lipophilic nature against bacteria and fungi.