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Dunaliella salina Extract Alleviates The Toxic Impact of Dioxin Induced Endocrine Disruption in Nile Tilapia

Article

Last updated: 22 Jan 2023

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Tags

Pharmaceutical Chemistry

Abstract

Pollution of lakes and seas in Egypt become a severe problem as it produces a lot of wastes and toxic chemicals. The water pollution induces a lot of endocrine disruptions in aquatic organisms. Several endocrine organs are influencing by pollution such as testes, ovaries, pituitary, hypothalamus, thyroid, and adrenal organs. Propositions of upsetting endocrine chemicals (EDCs) can meddle with fish larval advancement affecting the delicate balance of the biological ecosystem. Endocrine disruption effects on reproductive cycles may affect reproductive behaviour and the development of secondary sexual characteristics. So the main objective of this research is to use marine algae, Dunaliella salina, extract in fish immunity enhancement against pollutants. Nile tilapia fish were exposed to Dioxin (as the main pollutant in the Egyptian environment) after feeding on algae extracts for one month. The results revealed that Dunaliella salina was able to protect the fish against pollution as it enhances the immune capability of Nile tilapia fish due to increase the levels of the antioxidant enzymes and decrease the protein oxidation.
Additionally, Dunaliella salina extract was able to decrease the alteration in the expression of genes encoding endocrine hormones such as LH and FSH in the pituitary of Nile tilapia exposed to Dioxin in comparison to control fish. Moreover, the Dunaliella salina extract decreased significantly the DNA damage in brain tissues of Nile tilapia exposed to Dioxin compared with control fish. The results conclude that Dunaliella salina could be used as ameliorative compounds against toxicity of Dioxin.

DOI

10.21608/ejchem.2019.16475.2006

Keywords

Marine algae extract, Water Pollution, endocrine disruption, Gene expression, DNA damage

Authors

First Name

Samah

Last Name

Bassem

MiddleName

-

Affiliation

Center of research and applied studies for climate change and sustainable development, Water Pollution Research Department, CEAS, National Research Centre(NRC), 33 El Bohouth st. (former El Tahrir st.), Dokki, Giza, Egypt, P. O.12622.

Email

samahbassem7@gmail.com

City

Giza

Orcid

-

First Name

Marwa I.

Last Name

Abd El Tawab

MiddleName

-

Affiliation

Center of research and applied studies for climate change and sustainable development, Water Pollution Research Department, CEAS, National Research Centre(NRC), 33 El Bohouth st. (former El Tahrir st.), Dokki, Giza, Egypt, P. O.12622.

Email

-

City

-

Orcid

-

First Name

Tarek

Last Name

Temraz

MiddleName

-

Affiliation

Marine Science Department, Faculty of Science, Suez Canal University, Ismailia, Egypt

Email

ttemraz@yahoo.com

City

Ismailia

Orcid

-

First Name

Wagdy

Last Name

Bassaly

MiddleName

Khalil

Affiliation

Cell Biology Department Genetic Engineering and Biotechnology Division ,National Research Centre , Dokki,Giza

Email

wbassaly@gmail.com

City

Giza

Orcid

-

First Name

Farouk K.

Last Name

El-baz

MiddleName

-

Affiliation

Plant Biochemistry Department, National Research Centre (NRC), 33 El Bohouth st. (former El Tahrir st.), Dokki, Giza, Egypt, P. O.12622

Email

-

City

-

Orcid

-

First Name

Gamila

Last Name

Ali

MiddleName

-

Affiliation

Water Pollution Research Department, National Research Centre (NRC), 33 El Bohouth st. (Former El Tahrir st.), Dokki, Giza, Egypt, P. O.12622

Email

gamilaali2003@gmail.com

City

Giza

Orcid

-

First Name

Fagr

Last Name

Abdel Gawad

MiddleName

Khamis

Affiliation

Water Pollution Research Dept., Environmental Research Division, National Research Centre , Dokki , Giza

Email

fagrabdlgawad@gmail.com

City

Giza

Orcid

-

Volume

63

Article Issue

5

Related Issue

10591

Issue Date

2020-05-01

Receive Date

2019-09-02

Publish Date

2020-05-01

Page Start

1,787

Page End

1,798

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 5_Pages 1787-1798.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_53690.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=53690

Order

15

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023