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69525

Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Synthesis and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated –NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.

DOI

10.21608/ejchem.2020.21193.2263

Keywords

Melatonin drug, Synthesis, Antimicrobial, complexes, ligand

Authors

First Name

Asma

Last Name

Al-Wasidi

MiddleName

S.

Affiliation

Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia

Email

asmachem7@hotmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Naglah

MiddleName

M.

Affiliation

Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622- Dokki, Cairo, Egypt

Email

amnaglah@gmail.com

City

-

Orcid

-

First Name

Moamen

Last Name

Refat

MiddleName

-

Affiliation

Taif University

Email

msrefat@yahoo.com

City

-

Orcid

-

First Name

Samy

Last Name

El-Megharbel

MiddleName

M.

Affiliation

El-Tahreer str 456

Email

samyegharbel@gmail.com

City

Geza

Orcid

-

First Name

Atef

Last Name

Kalmouch

MiddleName

-

Affiliation

Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622- Dokki, Cairo, Egypt

Email

akalmoush@hotmail.com

City

-

Orcid

-

First Name

Gaber

Last Name

Moustafa

MiddleName

Osman Mohamed

Affiliation

El-Tahreer str 456

Email

gosman79@gmail.com

City

Geza

Orcid

-

Volume

63

Article Issue

4

Related Issue

10590

Issue Date

2020-04-01

Receive Date

2019-12-19

Publish Date

2020-04-01

Page Start

1,469

Page End

1,481

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 4_Pages 1469-1481.pdf

PDF . 1.8MB

Link

https://ejchem.journals.ekb.eg/article_69525.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=69525

Order

22

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Spectroscopic Characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

Details

Type

Article

Created At

22 Jan 2023