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58188

Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

Abstract A novel series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents.

DOI

10.21608/ejchem.2019.16920.2030

Keywords

Keywords: Antimicrobial, antioxidant, Docking study, 2-Aminophenol, Benzoxazinone, Hydrazide

Authors

First Name

Helen

Last Name

Mhmood

MiddleName

abdalhassan

Affiliation

Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq

Email

helenabdalhassan1979@gmail.com

City

Baghdad

Orcid

0000-0001-6977-1792

First Name

souad

Last Name

Lafta

MiddleName

Jabbar

Affiliation

Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq.

Email

souadj1955@gmail.com

City

Baghdad

Orcid

0000-0002-7136-0666

First Name

Abdul Jabar

Last Name

Atia

MiddleName

Khalf

Affiliation

Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq.

Email

chemabduiljabar1971@gmail.com

City

Baghdad

Orcid

-

First Name

Redha

Last Name

Al-Bayati

MiddleName

Ibrahim

Affiliation

Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq.

Email

dr.redhaalbayati@gmail.com

City

Baghdad

Orcid

-

First Name

ahmed

Last Name

abdula

MiddleName

mutanabbi

Affiliation

chemistry, college of science, Mustansiriyah university

Email

ahm.chem@yahoo.com

City

Baghdad

Orcid

0000-0002-6321-0555

Volume

63

Article Issue

1

Related Issue

10554

Issue Date

2020-01-01

Receive Date

2019-09-13

Publish Date

2020-01-01

Page Start

225

Page End

238

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 63_Issue 1_Pages 225-238.pdf

PDF . 2.1MB

Link

https://ejchem.journals.ekb.eg/article_58188.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=58188

Order

19

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives

Details

Type

Article

Created At

22 Jan 2023