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45118

Design and Facile Synthesis of New Bioactive C-glycosidic Semi-Natural Compounds

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Organic chemistry

Abstract

Objective: The presented work aims to synthesize new bioactive molecules of wide spectrum biological activity. In this study, a new series of α,β unsaturated ketones having acylic sugar residue was synthesized along with their hydrazone analogues.
Methods: Those new compounds were obtained via mild condensation reactions to avoid side products and were investigated by spectral analysis including IR, 1HNMR,13CNMR and mass spectrometer. In addition, they were tested and evaluated as antimicrobial and antioxidant agents.
Novelty: Results revealed that compound 2d is the most promising antimicrobial agent among the tested compounds and it even exceeds the activity of the used standard antibacterial drug Ampicillin as well as it competes with the standard antifungal drug Amphotericin B. On the other hand, compound 3b shows potent antioxidant activity in comparison with the used standard drug Trolox. Structure-activity relationship is also discussed.

DOI

10.21608/ejchem.2019.14209.1875

Keywords

Bioactive molecules, C-glycosides, antioxidant, Antimicrobial, acetylfuran

Authors

First Name

Galal

Last Name

Nawwar

MiddleName

Abd El-Moein

Affiliation

Green chemistry department, National Research Centre

Email

gnawwar@yahoo.com

City

-

Orcid

-

First Name

Maher

Last Name

Al-Hashash

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Ain-shams University

Email

maher_elhashash@sci.asu.edu.eg

City

-

Orcid

-

First Name

Randa

Last Name

Swellam

MiddleName

Helmy

Affiliation

green chemistry department, National Research Centre

Email

rh.maamoun@nrc.sci.eg

City

-

Orcid

-

First Name

Hoda

Last Name

Othman

MiddleName

Sabry

Affiliation

Green Chemistry department, National research centre

Email

hoda_sabry2@yahoo.com

City

-

Orcid

-

Volume

63

Article Issue

1

Related Issue

10554

Issue Date

2020-01-01

Receive Date

2019-07-01

Publish Date

2020-01-01

Page Start

185

Page End

195

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_45118.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=45118

Order

15

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Design and Facile Synthesis of New Bioactive C-glycosidic Semi-Natural Compounds

Details

Type

Article

Created At

22 Jan 2023