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34213

Silica sulfuric acid / ethylene glycol: An Efficient Eco-friendly Catalyst for One-pot Synthesis of Tricyclic and Tetarcyclic Dihydropyrimidine Derivatives.

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Organic chemistry

Abstract

A simple and efficient eco-friendly chemical procedures were developed for the synthesis of series of tricyclic and tetarcyclic dihydropyrimidine derivatives in excellent yields via a one-pot, multi-component reaction in the presence of silica sulfuric acid / ethylene glycol catalyst. The Tricyclic dihydropyrimidine derivatives 1a-g (benzo[4,5]imidazo[1,2-a]pyrimidine derivatives) were synthesized in high yields and high purity with short reaction times by reacting 2-aminobenzimidazole, aldehydes and ethyl acetoacetate. Also, the tetracyclic dihydropyrimidine derivatives 3a-f (benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives) were synthesized by the reaction of 2-aminobenzimidazole, aldehydes and cyanoacetamide. This present new protocol offers shorter reaction time, high yields and low cost. This method provides much improved protocol over the existing methods.

DOI

10.21608/ejchem.2019.13142.1827

Keywords

Silica sulfuric acid/ethylene glycol, Dihydropyrimidine derivatives Benzo[4,5]imidazo[1,2-a]pyrimidine, 2-Aminobenzimidazole

Authors

First Name

Nagwa

Last Name

Abdelazeem

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

Email

nagwamorad@yahoo.com

City

-

Orcid

https://orcid.org/00

First Name

Wahid

Last Name

Basyouni

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

Email

w_basyouni2002@yahoo.com

City

-

Orcid

-

First Name

Samir

Last Name

Abbas

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

Email

samiryoussef98@yahoo.com

City

-

Orcid

-

First Name

Khairy

Last Name

El-Bayouki

MiddleName

-

Affiliation

Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.

Email

khelbayouki@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

El-kady

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Ain Shams University

Email

samiryoussef@rocketmail.com

City

-

Orcid

-

Volume

62

Article Issue

12

Related Issue

9517

Issue Date

2019-12-01

Receive Date

2019-05-27

Publish Date

2019-12-01

Page Start

2,265

Page End

2,276

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 62_Issue 12_Pages 2265-2276.pdf

PDF . 1.3MB

Link

https://ejchem.journals.ekb.eg/article_34213.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=34213

Order

8

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Silica sulfuric acid / ethylene glycol: An Efficient Eco-friendly Catalyst for One-pot Synthesis of Tricyclic and Tetarcyclic Dihydropyrimidine Derivatives.

Details

Type

Article

Created At

22 Jan 2023