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Isolation and Structure Elucidation of Compounds from Coccinia grandis Leaves Extract

Article

Last updated: 01 Jan 2025

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-

Tags

Pharmaceutical Chemistry

Abstract

In this study, preliminary phytochemical screening of dried leaves of Coccinia grandis showed presence of triterpenoids, phenolics, flavonoids, saponins and sterols. As well as, five phenolic compounds namely; ferulic acid (1), methyl caffeate (2), ligstroside(3), trans-p- coumaric acid (4) and kaempferol-3-O-β-D-glucoside (5) were isolated from selected fraction of the methanol extract of Coccinia grandis leaves. The structures of the isolated compounds were identified using different NMR spectroscopic techniques (1H, 13C NMR, COSY, HSQC, HMBC) and mass spectrometry. Compounds (1), (2), (4) and (5) were isolated for the first time from Coccinia grandis species while compound (3) was isolated for the first time from Cucurbitaceae family. Moreover, the anti-microbial activity of the selected fraction of the methanol extract of Coccinia grandis leaves was tested against a panel of Gram-positive, Gram-negative bacteria and yeast. A considered activity was recorded against Bacillus cereus (inhibition zone of 20 mm with MIC 1mg/ml).

DOI

10.21608/ejchem.2019.10925.1700

Keywords

Coccinia grandis, Phenolics, Flavonoids, NMR, MS, Anti-microbial activity

Authors

First Name

Somaia. A.

Last Name

Al-Madhagy

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University. Cario, Egypt, , Pharmacognosy Department, Faculty of Pharmacy, Sana'a University. Sana'a, Yemen

Email

almathaji84@hotmail.com

City

-

Orcid

-

First Name

Nada M.

Last Name

Mostafa

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University. Cario, Egypt,

Email

nadamostafa@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Fadia S.

Last Name

Youssef

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University. Cario, Egypt,

Email

fadiayoussef@pharma.asu.edu.eg

City

-

Orcid

-

First Name

Ghada. E. A.

Last Name

Awad

MiddleName

-

Affiliation

Chemistry of Natural and Microbial Products Department. Pharmaceutical and Drug industries research Division. National Research Centre. Giza, Egypt

Email

-

City

-

Orcid

-

First Name

Omayma A.

Last Name

Eldahshan

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University. Cario, Egypt,

Email

omiahm@hotmail.com

City

-

Orcid

-

First Name

Abdel Nasser B.

Last Name

Singab

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Ain Shams University. Cario, Egypt,

Email

dean@pharma.asu.edu.eg

City

-

Orcid

-

Volume

62

Article Issue

10

Related Issue

7820

Issue Date

2019-10-01

Receive Date

2019-03-20

Publish Date

2019-10-01

Page Start

1,869

Page End

1,877

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 62_Issue 10_Pages 1869-1877.pdf

PDF . 1.5MB

Link

https://ejchem.journals.ekb.eg/article_30035.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=30035

Order

8

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Isolation and Structure Elucidation of Compounds from Coccinia grandis Leaves Extract

Details

Type

Article

Created At

22 Jan 2023